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Daawoonline Information Advanced search The team Delete all board cookies All times are UTC [ DST ]Montelukast Sodium: Administration Children Control Intermittent Asthm Montelukast Sodium: Administration to Children to Control Intermittent AsthmaThe prototype cysteinyl leukotriene receptor antagonist, montelukast, is generally considered to have a niche application in the chemotherapy of exercise-induced asthma. It has also been used as add-on therapy in patients whose asthma is poorly controlled with inhaled corticosteroid monotherapy, or with the combination of a long-acting ?(2)-agonist and an inhaled corticosteroid. Recently, however, montelukast has been reported to possess secondary anti-inflammatory properties, apparently unrelated to conventional antagonism of cysteinyl leukotriene receptors. These novel activities enable montelukast to target eosinophils, monocytes, and, in particular, the corticosteroid-insensitive neutrophil, suggesting that this agent may have a broader spectrum of anti-inflammatory activities than originally thought. If so, montelukast is potentially useful in the chemotherapy of intermittent asthma because most exacerbations of this condition involve respiratory virus infection-triggered inflammatory mechanisms which, to a large extent, involve airway epithelial cell/neutrophil interactions. The primary objective of this review is to evaluate the role of montelukast in the treatment of intermittent asthma in children. A clinical review of montelukast in the treatment of seasonal allergic rhinitis - NeLM A clinical review of montelukast in the treatment of seasonal allergic rhinitis CRD summary: This review aimed to compare the efficacy of montelokast with current therapies for seasonal allergic rhinitis. The authors concluded that there was no evidence to support the use of montelokast (alone or in combination with antihistamines) over intranasal corticosteroids. Limitations in the review methods and the reporting of included studies mean that these conclusions should be viewed with caution. CRD commentary: The review question was clearly stated. However, the authors did not specify any inclusion criteria for the outcome measures, beyond the statement that they aimed to assess efficacy, safety and tolerability. The search was limited to two electronic databases and only literature published in English was included. Hence, it is possible that relevant studies were missed and that language and/or publication bias might have been present. No details of the review process were reported, thus it was not possible to assess whether steps were taken to reduce errors and/or reviewer bias. The results of the included studies were tabulated and discussed in a narrative in which studies were grouped by comparator (placebo or active control). The narrative lacked an overall summary and focused on reporting the individual study results. Some potentially important study details were not presented, e.g. the number of participants in each treatment arm and baseline characteristics. Given these limitations, the conclusions of the review should be interpreted with caution.
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